Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission
نویسندگان
چکیده
منابع مشابه
Nature of cross-seeding barriers of amyloidogenesis.
The epidemics of bovine spongiform encephalopathy (BSE) several decades ago and present epidemics of chronic wasting disease (CWD) among cervids posed a threat of cross-species infections to humans or other animals. Therefore, the question as to the molecular nature of the species barriers to transmissibility of prion diseases is very important. We approached this problem theoretically, first d...
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This research studies the optimal seeding of a network of consumers who are potential adopters of a technology. This problem has a wide range of applications which include launching a network good, inducing network-based marketing, igniting collaboration in organizations, and stimulating R&D with local spillovers. I have two main results so far. The first result shows that when a firm is unawar...
متن کاملCross-seeding effects of amyloid β-protein and α-synuclein.
Amyloid β-protein (Aβ) and α-synuclein (αS) are the primary components of amyloid plaques and Lewy bodies (LBs), respectively. Previous in vitro and in vivo studies have suggested that interactions between Aβ and αS are involved in the pathogenesis of Alzheimer's disease and LB diseases. However, the seeding effects of their aggregates on their aggregation pathways are not completely clear. To ...
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Destabilized mutant p53s coaggregate with WT p53, p63, and p73 in cancer cell lines. We found that stoichiometric amounts of aggregation-prone mutants induced only small amounts of WT p53 to coaggregate, and preformed aggregates did not significantly seed the aggregation of bulk protein. Similarly, p53 mutants trapped only small amounts of p63 and p73 into their p53 aggregates. Tetrameric full-...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2017
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a024323